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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated: 2017 Aug. 1
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Warning
– Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite
Conservation Score
Human Protein:
HSP90AA1
All Species:
52.42
Human Site:
Y492
Identified Species:
88.72
UniProt:
P07900
Number Species:
13
Phosphosite Substitution
Charge Score:
0
Phosphosite
Sequences
Species
Species
Scientific Name
UniProt ID
NCBI Ref Seq ID
AA#
Mr(Da)
P-Site
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Human
Homo sapiens
P07900
NP_001017963.2
732
84660
Y492
K
E
N
Q
K
H
I
Y
Y
I
T
G
E
T
K
Chimpanzee
Pan troglodytes
A5A6K9
733
84754
Y493
K
E
N
Q
K
H
I
Y
Y
I
T
G
E
T
K
Rhesus Macaque
Macaca mulatta
XP_001098520
724
83571
Y484
K
E
T
Q
K
S
I
Y
Y
I
T
G
E
S
K
Dog
Lupus familis
Cat
Felis silvestris
Mouse
Mus musculus
P07901
733
84769
Y493
K
E
N
Q
K
H
I
Y
F
I
T
G
E
T
K
Rat
Rattus norvegicus
P82995
733
84796
Y493
K
E
N
Q
K
H
I
Y
F
I
T
G
E
T
K
Wallaby
Macropus eugenll
Platypus
Ornith. anatinus
XP_001512830
733
84847
Y493
K
E
N
Q
K
H
I
Y
Y
I
T
G
E
T
K
Chicken
Gallus gallus
P11501
728
84041
Y488
K
E
N
Q
K
H
V
Y
Y
I
T
G
E
T
K
Frog
Xenopus laevis
NP_001085598
729
84174
Y489
K
E
N
Q
K
H
I
Y
Y
I
T
G
E
T
K
Zebra Danio
Brachydanio rerio
Q90474
725
83300
Y485
K
D
T
Q
K
H
I
Y
Y
I
T
G
E
T
K
Tiger Blowfish
Takifugu rubipres
Fruit Fly
Dros. melanogaster
P02828
717
81847
Y477
K
D
N
Q
K
H
V
Y
F
I
T
G
E
S
K
Honey Bee
Apis mellifera
XP_395168
718
82735
Y480
K
E
N
Q
K
H
I
Y
F
I
T
G
E
S
K
Nematode Worm
Caenorhab. elegans
Q18688
702
80265
Y462
K
E
N
Q
T
Q
I
Y
Y
I
T
G
E
S
K
Sea Urchin
Strong. purpuratus
Poplar Tree
Populus trichocarpa
Maize
Zea mays
Q08277
715
81872
Y478
K
E
G
Q
K
D
I
Y
Y
I
T
G
E
S
R
Rice
Oryza sativa
Thale Cress
Arabidopsis thaliana
P27323
700
80617
F464
K
E
G
Q
K
D
I
F
Y
I
T
G
E
S
K
Baker's Yeast
Sacchar. cerevisiae
Red Bread Mold
Neurospora crassa
Conservation
Percent
Protein Identity:
100
99.7
83
N.A.
N.A.
99
99.1
N.A.
95.9
96.1
91.9
85.3
N.A.
77.5
81.2
74.4
N.A.
Protein Similarity:
100
99.7
90.1
N.A.
N.A.
99.7
99.7
N.A.
98.2
97.6
96
93.5
N.A.
88.1
90.4
86
N.A.
P-Site Identity:
100
100
80
N.A.
N.A.
93.3
93.3
N.A.
100
93.3
100
86.6
N.A.
73.3
86.6
80
N.A.
P-Site Similarity:
100
100
86.6
N.A.
N.A.
100
100
N.A.
100
100
100
93.3
N.A.
100
100
86.6
N.A.
Percent
Protein Identity:
N.A.
68.5
N.A.
70.2
N.A.
N.A.
Protein Similarity:
N.A.
82.5
N.A.
82.9
N.A.
N.A.
P-Site Identity:
N.A.
73.3
N.A.
73.3
N.A.
N.A.
P-Site Similarity:
N.A.
86.6
N.A.
86.6
N.A.
N.A.
Phosphosite
Consensus
Position
-7
-6
-5
-4
-3
-4
-5
0
+1
+2
+3
+4
+5
+6
+7
% Ala:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% A
% Cys:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% C
% Asp:
0
15
0
0
0
15
0
0
0
0
0
0
0
0
0
% D
% Glu:
0
86
0
0
0
0
0
0
0
0
0
0
100
0
0
% E
% Phe:
0
0
0
0
0
0
0
8
29
0
0
0
0
0
0
% F
% Gly:
0
0
15
0
0
0
0
0
0
0
0
100
0
0
0
% G
% His:
0
0
0
0
0
72
0
0
0
0
0
0
0
0
0
% H
% Ile:
0
0
0
0
0
0
86
0
0
100
0
0
0
0
0
% I
% Lys:
100
0
0
0
93
0
0
0
0
0
0
0
0
0
93
% K
% Leu:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% L
% Met:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% M
% Asn:
0
0
72
0
0
0
0
0
0
0
0
0
0
0
0
% N
% Pro:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% P
% Gln:
0
0
0
100
0
8
0
0
0
0
0
0
0
0
0
% Q
% Arg:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
8
% R
% Ser:
0
0
0
0
0
8
0
0
0
0
0
0
0
43
0
% S
% Thr:
0
0
15
0
8
0
0
0
0
0
100
0
0
58
0
% T
% Val:
0
0
0
0
0
0
15
0
0
0
0
0
0
0
0
% V
% Trp:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% W
% Tyr:
0
0
0
0
0
0
0
93
72
0
0
0
0
0
0
% Y
% Spaces:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% _